FR054

英文名	FR054	CAS號(hào)	35954-65-5
產(chǎn)品編號(hào)	FSY0336	分子式	C₁₄H₁₉NO₈
產(chǎn)品分類	化合物與抑制劑	分子量	329.30256
純度	≥95.0%	儲(chǔ)存條件	-20°C

大包裝詢盤

產(chǎn)品簡(jiǎn)介

FR054 是 HBO 酶 PGM3 的抑制劑，具有明顯的抗乳腺癌活性。

生物活性

FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect.

體外研究

FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects.
FR054 (250 μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells.
FR054 induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptotic cell death.

Cell Viability Assay

Cell Line:	MDA-MB-231 cells.
Concentration:	0.5-1 mM.
Incubation Time:	48 h.
Result:	Reduced viability and a significant increase of the apoptosis as compared to the control clone.

體內(nèi)研究

FR054 (1000 mg/kg, ip) suppresses cancer growth in MDA-MB-231 xenograft mice.

Animal Model:	Mice were subcutaneously injected with MDA-MB-231 cells.
Dosage:	1000 mg/kg.
Administration:	IP, single or fractionated dose (twice a day 500 mg/kg/dose).
Result:	Appears to have an in vivo antitumor efficacy that is higher when administered twice a day compared to single administration.

分子式

C14H19NO8

分子量

329.30

CAS號(hào)

35954-65-5

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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