FR054

英文名	FR054	CAS號(hào)	35954-65-5
產(chǎn)品編號(hào)	FSY0336	分子式	C₁₄H₁₉NO₈
產(chǎn)品分類	化合物與抑制劑	分子量	329.30256
純度	≥95.0%	儲(chǔ)存條件	-20°C

大包裝詢盤

產(chǎn)品簡(jiǎn)介

FR054 是 HBO 酶 PGM3 的抑制劑，具有明顯的抗乳腺癌活性。

生物活性

FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect.

體外研究

FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects.
FR054 (250 μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells.
FR054 induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptotic cell death.

Cell Viability Assay

Cell Line:	MDA-MB-231 cells.
Concentration:	0.5-1 mM.
Incubation Time:	48 h.
Result:	Reduced viability and a significant increase of the apoptosis as compared to the control clone.

體內(nèi)研究

FR054 (1000 mg/kg, ip) suppresses cancer growth in MDA-MB-231 xenograft mice.

Animal Model:	Mice were subcutaneously injected with MDA-MB-231 cells.
Dosage:	1000 mg/kg.
Administration:	IP, single or fractionated dose (twice a day 500 mg/kg/dose).
Result:	Appears to have an in vivo antitumor efficacy that is higher when administered twice a day compared to single administration.

分子式

C14H19NO8

分子量

329.30

CAS號(hào)

35954-65-5

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

综合伊人,久久精品一区二区免费播,a视频在线亚洲,久久久久午夜精品色av

免疫學(xué)產(chǎn)品

細(xì)胞生物學(xué)產(chǎn)品

分子生物學(xué)產(chǎn)品

生化試劑產(chǎn)品

科研耗材

儀器設(shè)備

技術(shù)服務(wù)

FR054

相關(guān)產(chǎn)品

產(chǎn)品全面

優(yōu)質(zhì)采購(gòu)方案

正品保障

急速物流

售后無(wú)憂

新手入門

配送服務(wù)

售后服務(wù)

會(huì)員中心

關(guān)于我們