GLUT inhibitor-1
| 英文名 | GLUT inhibitor-1 | CAS號 | 2421141-40-2 |
| 產品編號 | FSY0344 | 分子式 | C32H35N7O2 |
| 產品分類 | 化合物與抑制劑 | 分子量 | 549.67 |
| 純度 | ≥98% | 儲存條件 | -20℃ |
產品簡介
GLUT inhibitor-1 是一種有效且具有口服活性的葡萄糖轉運蛋白抑制劑，靶向 GLUT1 和 GLUT3，IC50s 值分別為 242 nM 和 179 nM。GLUT inhibitor-1 具有研究癌癥和自身免疫性疾病的潛力。
GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.
靶點活性：GLUT3:179 nM (IC50), GLUT1:242 nM (IC50)
體內活性：GLUT inhibitor-1 exhibits good oral pharmacokinetic parameters in mice and rats with oral Cmax values of 2525 and 1675 ng/mL, AUCs of 5890 and 6813 ng/mL, CLs of 40 and 37 mL/min/kg, Vdss of 1.70 and 4.51 L/Kg, t1/2s of 0.785 and 2.59h and Fs of 45.4% and 49.4%[1].
CAS No：2421141-40-2
分子量：549.67
分子式：C32H35N7O2
存儲Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度
DMSO: 90mg/mL (163.7mM), ultrasonic and warming and heat to 60°C
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